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The anti-oxidative stress response in Drosophila malanogaster involvement of adipokinetic hormone and adenosine
 Zemanová, Milada ; Kodrík, Dalibor
The anti-oxidative stress response was studied in Drosophila melanogaster larvae and adults with mutation in genes of adipokinetic hormone (Akh), and adenosine receptor (AdoR(1)), and both these genes together (Akh(1) AdoR1 double mutant). To elicit the oxidative stress we administered paraquat (PQ) in food. Mortality tests revealed the double mutant Akh(1) AdoR(1) was more sensitive to PQ toxicity than either of the single mutants. The PQ administration significantly increased the Drome-AKH hormone level in control w(1118) and AdoR(1) larvae. On the contrary, PQ significantly increased expression of glutathione S-transferase D1 (GstD1) gene. It seems that both functional adenosine receptor and AKH itself are important for the proper control of the GstD1 gene expression under oxidative stress. On the other hand, differences in glutathione S-transferase (GST) activity among the strains, and between untreated and PQ treated groups were minimal. Next, the glutathione (GSH) level was significantly lower in all untreated mutant groups as compared with untreated control w1118 flies and declined further when the flies were treated with PQ. Thus, we demonstrated the important role of AKH and adenosine in control of anti-stress response elicited by PQ in D. melanogaster model.
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